Vatalanib decrease the positive interaction of VEGF receptor-2 and P2X2/3 receptor in chronic constriction injury rats.

@article{Liu2012VatalanibDT,
  title={Vatalanib decrease the positive interaction of VEGF receptor-2 and P2X2/3 receptor in chronic constriction injury rats.},
  author={Shuangmei Liu and Changshui Xu and Guilin Li and Hao Liu and Jinyan Xie and Guihua Tu and Haiying Peng and Shuyi Qiu and Shangdong Liang},
  journal={Neurochemistry international},
  year={2012},
  volume={60 6},
  pages={565-72}
}
Neuropathic pain can arise from a lesion affecting the peripheral nervous system. Selective P2X(3) and P2X(2/3) receptors' antagonists effectively reduce neuropathic pain. VEGF inhibitors are effective for pain relief. The present study investigated the effects of Vatalanib (VEGF receptor-2 (VEGFR-2) inhibitor) on the neuropathic pain to address the interaction of VEGFR-2 and P2X(2/3) receptor in dorsal root ganglia of chronic constriction injury (CCI) rats. Neuropathic pain symptoms following… CONTINUE READING

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Co - expression of VEGFR-2 and P2X(2 ) or P2X(3 ) in L4 - 6 dorsal root ganglia ( DRG ) was detected by double - label immunofluorescence .
Co - expression of VEGFR-2 and P2X(2 ) or P2X(3 ) in L4 - 6 dorsal root ganglia ( DRG ) was detected by double - label immunofluorescence .
Co - expression of VEGFR-2 and P2X(2 ) or P2X(3 ) in L4 - 6 dorsal root ganglia ( DRG ) was detected by double - label immunofluorescence .
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