Vaspin inhibits kallikrein 7 by serpin mechanism

@inproceedings{Heiker2013VaspinIK,
  title={Vaspin inhibits kallikrein 7 by serpin mechanism},
  author={John T Heiker and Nora Kl{\"o}ting and Peter Kovacs and E. Bartholomeus Kuettner and Norbert Str{\"a}ter and Stephan Schultz and Matthias Robert Kern and Michael Stumvoll and Matthias Blueher and Annette G Beck-Sickinger},
  booktitle={Cellular and Molecular Life Sciences},
  year={2013}
}
The molecular target of the adipokine vaspin (visceral adipose tissue-derived serpin; serpinA12) and its mode of action are unknown. Here, we provide the vaspin crystal structure and identify human kallikrein 7 (hK7) as a first protease target of vaspin inhibited by classical serpin mechanism with high specificity in vitro. We detect vaspin–hK7 complexes in human plasma and find co-expression of both proteins in murine pancreatic β-cells. We further demonstrate that hK7 cleaves human insulin in… CONTINUE READING

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