Vasotab, a vasoactive peptide from horse fly Hybomitra bimaculata (Diptera, Tabanidae) salivary glands.

@article{Tak2006VasotabAV,
  title={Vasotab, a vasoactive peptide from horse fly Hybomitra bimaculata (Diptera, Tabanidae) salivary glands.},
  author={Peter Tak{\'a}{\vc} and Miles A. Nunn and J{\'a}nos M{\'e}sz{\'a}ros and Olga Pechanova and Norbert Vrbjar and Petra Vlas{\'a}kov{\'a} and Milan Koz{\'a}nek and M{\'a}ria Kazim{\'i}rov{\'a} and George F. Hart and Patricia A Nuttall and Milan Labuda},
  journal={The Journal of experimental biology},
  year={2006},
  volume={209 Pt 2},
  pages={343-52}
}
Horse flies feed from superficial haematomas and probably rely heavily on the pharmacological properties of their saliva to find blood. Here we describe the first evidence of vasodilators in horse fly Hybomitra bimaculata (Diptera, Tabanidae) salivary gland extract and clone and express one of the active peptides (termed vasotab). Physiological tests using crude salivary gland extracts and reverse-phase HPLC fractions demonstrated positive inotropism in isolated rat hearts, vasodilatation of… CONTINUE READING