Vasorelaxant effect of quercetin on cerebral basilar artery in vitro and the underlying mechanisms study

@article{Yuan2018VasorelaxantEO,
  title={Vasorelaxant effect of quercetin on cerebral basilar artery in vitro and the underlying mechanisms study},
  author={Tian-yi Yuan and Zi-ran Niu and Di Chen and Yu-cai Chen and Hui-fang Zhang and Lianhua Fang and Guan-hua Du},
  journal={Journal of Asian Natural Products Research},
  year={2018},
  volume={20},
  pages={477 - 487}
}
Abstract The aim of this study is to investigate the vasorelaxant effect of quercetin on cerebral basilar artery in vitro and provide a preliminary discussion concerning the underlying mechanisms. Using a DMT-isolated micro vessel system, quercetin was found to exhibit a vasodilatory effect on basilar arteries contracted by potassium chloride (KCl), endothelin-1 (ET-1), and 5-hydroxytryptamine (5-HT). The vasorelaxant effect of quercetin was partially attenuated when endothelium cells were… 
Vascular Effects of Polyphenols from Agrimonia eupatoria L. and Role of Isoquercitrin in Its Vasorelaxant Potential in Human Arteries
TLDR
Isoquercitrin elicited a vasoactivity consistent with the ethyl acetate fraction, suggesting this is a major component responsible for the vasorelaxant properties of A. eupatoria in human arteries.
Polyphenolic compounds of Euphorbia umbellata (Pax) Bruyns (Euphorbiaceae) improved endothelial dysfunction through arginase inhibition
TLDR
Oral treatment preserved endothelium‐dependent vasodilation through ARG inhibition together with an increase in l‐arginine bioavailability and endothelial NO synthase expression and the lack of toxicity for sub‐chronic treatment was determined.
The Effect of Dietary Polyphenols on Vascular Health and Hypertension: Current Evidence and Mechanisms of Action
The aim of this review was to explore existing evidence from studies conducted on humans and summarize the mechanisms of action of dietary polyphenols on vascular health, blood pressure and
Polyphenols: the hallmark of endothelial dysfunction combatants
Quercetin Exerts Age-Dependent Beneficial Effects on Blood Pressure and Vascular Function, But Is Inefficient in Preventing Myocardial Ischemia-Reperfusion Injury in Zucker Diabetic Fatty Rats
TLDR
QCT seems to be inefficient in preventing myocardial I/R injury in type 2 diabetes and/or higher age, and impaired activation of PI3K/Akt kinase pathway might be, at least in part, responsible for failing cardioprotection in subjects.

References

SHOWING 1-10 OF 48 REFERENCES
Effects of quercetin and rutin on vascular preparations
TLDR
The mechanical and electrophysiological properties of quercetin and its rutoside, rutin, are investigated in an attempt to clarify how Ca2+ channel activation might be related to the myorelaxing activity.
Endothelium-Independent Vasorelaxant Effect of Ligusticum jeholense Root and Rhizoma on Rat Thoracic Aorta
TLDR
The results suggested that LJE-induced vasorelaxation were related to blocking K+ channels and inhibiting entry of extracellular Ca2+ via receptor-operative Ca 2+ channels (ROCCs) or voltage-dependent Ca2 + channels (VDCCs).
Cannabinoid and lipid-mediated vasorelaxation in retinal microvasculature.
Effect of a chloride channel inhibitor, 5-nitro-2- (3-phenylpropylamino)-benzoate, on endothelin-1 induced vasoconstriction in rabbit basilar artery.
TLDR
Test the effect of 5-nitro-2-(3-phenylpropylamino)-benzoate (NPPB), a Cl- channel antagonist, on the ET-1-induced cerebral vasospasm in rabbit basilar artery to investigate the contribution of Cl- channels.
Partial role of multiple pathways in infarct size limiting effect of quercetin and rutin against cerebral ischemia-reperfusion injury in rats.
TLDR
Possible partial role of antioxidant, anti-inflammatory and involvement of NO in the beneficial effects of bioflavonoids quercetin and rutin against cerebral ischemia reperfusion injury was observed.
Vasodilator Compounds Derived from Plants and Their Mechanisms of Action
TLDR
It was found that many compounds induced vasodilation by more than one mechanism, and secondary metabolites, which include a significant group of compounds with extensive chemical diversity, are a valuable source of new pharmaceuticals useful for the treatment of cardiovascular diseases.
Cardiovascular Disease: A Target for the Pharmacological Effects of Quercetin.
TLDR
Evidence is presented supporting the point of view that quercetin should be considered a potential therapeutic agent against cardiovascular diseases, giving rise to novel applications in their prevention and treatment.
Developmental differences in Ca2+-activated K+ channel activity in ovine basilar artery.
TLDR
It is observed that at voltage-clamped membrane potentials of +60 mV in perforated whole cell studies, the normalized outward current densities in fetal myocytes were >30% higher than in those of the adult (P < 0.05) and that these were predominantly due to iberiotoxin-sensitive currents from BKCa channels.
...
...