Vasorelaxant effect of isoquinoline derivatives from two species of Popowia perakensis and Phaeanthus crassipetalus on rat aortic artery

  title={Vasorelaxant effect of isoquinoline derivatives from two species of Popowia perakensis and Phaeanthus crassipetalus on rat aortic artery},
  author={Kazumasa Zaima and Yuka Takeyama and Ikumi Koga and Aiko Saito and Haruka Tamamoto and Saripah Salbiah Syed Abdul Azziz and Mat Ropi Mukhtar and Khalijah Awang and A. Hamid A. Hadi and Hiroshi Morita},
  journal={Journal of Natural Medicines},
Five bisbenzyl isoquinolines (1–5), three benzyl isoquinolines (6–8), four isoquinoline alkaloids (9–12), and two unclassified compounds (13 and 14) from Popowia perakensis and Phaeanthus crassipetalus were evaluated for their vasorelaxant effect on rat aortic arteries. In aortic rings pre-contracted with phenylephrine (PE, 0.3 μM), some of the bisbenzyl isoquinoline alkaloids, benzyl isoquinoline alkaloids, and isoquinoline alkaloids showed clearly vasorelaxant effects at 30 μM. The action of… 

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