Vasorelaxant and antihypertensive effects of ZCM298, a dihydropyridine derivative, are through inhibiting extracellular calcium influx.

  title={Vasorelaxant and antihypertensive effects of ZCM298, a dihydropyridine derivative, are through inhibiting extracellular calcium influx.},
  author={Li-xin Zhang and Xinlin Chen and Peng-bo Yang and San-qi Zhang and Yong-xiao Cao},
  journal={Pharmacological reports : PR},
  volume={65 1},



Vasorelaxant and antihypertensive effects of formononetin through endothelium-dependent and -independent mechanisms

In spontaneously hypertensive rats, formononetin slowly lowered the systolic, diastolic and mean arterial pressure, probably due to inhibition of voltage-dependent Ca2+ channels and intracellular Ca2-free depolarized medium and by releasing NO.

Lacidipine, a new long-acting dihydropyridine calcium antagonist, has high vascular selectivity against all intracardiac variables

The results indicate that the vascular selectivity of lacidipine is markedly high not only against ventricular contractility but also against sinoatrial node automaticity and atrioventricular nodal conduction.

In vitro effects of the new calcium antagonist lacidipine.

The results suggest that LC is a potent, highly vascular-selective calcium antagonist with little cardiodepressant effects and as such may be suitable for the treatment of hypertension.

Regulation of renal artery smooth muscle tone by α1-adrenoceptors: role of voltage-gated calcium channels and intracellular calcium stores

The results suggest a key role of voltage-dependent Ca2+ channels and intracellular Ca2-sensitive stores in the α1A-adrenoceptor induced contraction of the renal artery.

Lacidipine: A Calcium Antagonist with Potent and Long‐Lasting Antihypertensive Effects in Animal Studies

In spontaneously hypertensive rats (SHR), lacidipine proved –30 times more potent, slower in onset, and longer-acting than nitrendipine in reducing blood pressure, and induced a natriuretic effect in saline-loaded SHR at antihypertensive doses.

The cellular mechanism of action of nimodipine (BAY e 9736), a new calcium antagonist [proceedings].

Preliminary experiments indicate that neostigmine enhances [3H]-noradrenaline overflow from the rat anococcygeus muscle during field stimulation and might elicit repetitive firing of motor nerve terminals in skeletal muscle by an effect unrelated to ChE inhibition.

Comparative study of calcium ion dynamics and contractile response in rat middle cerebral and basilar arteries.

Comparing intracellular calcium concentration and contractile responses in isolated rat middle cerebral artery with those in basilar artery employing real-time confocal laser microscopy revealed that different regions of arteries along the same cerebral tissue may display distinct [Ca(2+)](i) response.

Interaction between L-type Ca2+ channels and sarcoplasmic reticulum in the regulation of vascular tone in isolated rat small arteries.

The contribution of the SR function to Ca2- metabolism depends on the activity of dihydropyridine-sensitive Ca2+ channels, and the dysfunction of SR by ryanodine may impair the Ca2+.