Vasorelaxant action of aqueous extract of the leaves of Persea americana on isolated thoracic rat aorta.

@article{Owolabi2005VasorelaxantAO,
  title={Vasorelaxant action of aqueous extract of the leaves of Persea americana on isolated thoracic rat aorta.},
  author={Mbang Adeyemi Owolabi and Smith Ishmael Jaja and Herbert A. B. Coker},
  journal={Fitoterapia},
  year={2005},
  volume={76 6},
  pages={567-73}
}
The present study investigated the vasorelaxant action of the aqueous leaves extract of Persea americana on isolated rat aorta. The results showed that the extract produced significant vasorelaxation and that the effect is dependent on the synthesis or release of endothelium-derived relaxing factors (EDRFs) as well as the release of prostanoid. The extract also reduced vasoconstriction probably by inhibiting Ca2+ influx through calcium channels. 
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