Vasoreactivity of isolated aortic rings from dyslipidemic and insulin resistant inducible nitric oxide synthase knockout mice.

@article{Pathak2019VasoreactivityOI,
  title={Vasoreactivity of isolated aortic rings from dyslipidemic and insulin resistant inducible nitric oxide synthase knockout mice.},
  author={Priya Pathak and Jitendra S. Kanshana and BabuNageswar Kanuri and S. C. Rebello and Hobby Aggarwal and Kumaravelu Jagavelu and M. Dikshit},
  journal={European journal of pharmacology},
  year={2019},
  volume={855},
  pages={
          90-97
        }
}
Recent study from this lab indicated enhanced susceptibility of iNOS KO mice for diet induced obesity (DIO) and systemic insulin resistance (IR) as compared to C57BL/6 (WT) mice. The present study investigates aortic vasoreactivity in high fat diet (HFD) induced insulin resistant iNOS KO mice. WT and iNOS KO mice were fed with 45% HFD/10% LFD for ten weeks. Systemic IR was assessed via measurement of circulating lipids, glucose, and insulin; while phenylephrine (PE)/acetylcholine (ACh) induced… Expand
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