Vasopressin-stimulated CFTR Cl- currents are increased in the renal collecting duct cells of a mouse model of Liddle's syndrome.

@article{Chang2005VasopressinstimulatedCC,
  title={Vasopressin-stimulated CFTR Cl- currents are increased in the renal collecting duct cells of a mouse model of Liddle's syndrome.},
  author={Chiz-Tzung Chang and Marcelle Bens and Edith Hummler and Sheerazed Boulkroun and Laurent Schild and Jacques Teulon and Bernard C Rossier and Alain Vandewalle},
  journal={The Journal of physiology},
  year={2005},
  volume={562 Pt 1},
  pages={271-84}
}
Liddle's syndrome is a genetic form of hypertension linked to Na(+) retention caused by activating mutations in the COOH terminus of the beta or gamma subunit of the epithelial sodium channel (ENaC). In this study, we used the short-circuit current (I(sc)) method to investigate the effects of deamino-8-d-arginine vasopressin (dDAVP) on Na(+) and Cl(-) fluxes in primary cultures of cortical collecting ducts (CCDs) microdissected from the kidneys of mice with Liddle's syndrome carrying a stop… CONTINUE READING