Vasopressin regulates the renin-angiotensin-aldosterone system via V1a receptors in macula densa cells.

  title={Vasopressin regulates the renin-angiotensin-aldosterone system via V1a receptors in macula densa cells.},
  author={Toshinori Aoyagi and Yuichiro Izumi and Masami Hiroyama and Takanobu Matsuzaki and Yukiko Yasuoka and Atsushi Sanbe and Hiroki Miyazaki and Yoko Fujiwara and Yushi Nakayama and Yukimasa Kohda and Junji Yamauchi and Takeaki Inoue and Katsumasa Kawahara and Hideyuki Saito and Kimio Tomita and Hiroshi Nonoguchi and Akito Tanoue},
  journal={American journal of physiology. Renal physiology},
  volume={295 1},
The neuropeptide hormone arginine-vasopressin (AVP) is well known to exert its antidiuretic effect via the vasopressin V2 receptor (V2R), whereas the role of the vasopressin V1a receptor (V1aR) in the kidney remains to be clarified. Previously, we reported decreased plasma volume and blood pressure in V1a receptor-deficient (V1aR-/-) mice (Koshimizu T, Nasa Y, Tanoue A, Oikawa R, Kawahara Y, Kiyono Y, Adachi T, Tanaka T, Kuwaki T, Mori T. Proc Natl Acad Sci USA 103: 7807-7812, 2006). In this… 

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