Vasopressin regulates the renin-angiotensin-aldosterone system via V1a receptors in macula densa cells.

@article{Aoyagi2008VasopressinRT,
  title={Vasopressin regulates the renin-angiotensin-aldosterone system via V1a receptors in macula densa cells.},
  author={Toshinori Aoyagi and Yuichiro Izumi and Masami Hiroyama and Takanobu Matsuzaki and Yukiko Yasuoka and Atsushi Sanbe and Hiroki Miyazaki and Yoko Fujiwara and Yushi Nakayama and Yukimasa Kohda and Junji Yamauchi and Takeaki Inoue and Katsumasa Kawahara and Hideyuki Saito and Kimio Tomita and Hiroshi Nonoguchi and Akito Tanoue},
  journal={American journal of physiology. Renal physiology},
  year={2008},
  volume={295 1},
  pages={
          F100-7
        }
}
The neuropeptide hormone arginine-vasopressin (AVP) is well known to exert its antidiuretic effect via the vasopressin V2 receptor (V2R), whereas the role of the vasopressin V1a receptor (V1aR) in the kidney remains to be clarified. Previously, we reported decreased plasma volume and blood pressure in V1a receptor-deficient (V1aR-/-) mice (Koshimizu T, Nasa Y, Tanoue A, Oikawa R, Kawahara Y, Kiyono Y, Adachi T, Tanaka T, Kuwaki T, Mori T. Proc Natl Acad Sci USA 103: 7807-7812, 2006). In this… 
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45 References

V1a vasopressin receptors maintain normal blood pressure by regulating circulating blood volume and baroreflex sensitivity

Results indicate that the V1a receptor plays an important role in normal resting arterial BP regulation mainly by its regulation of circulating blood volume and baroreflex sensitivity.

Alteration of glucose homeostasis in V1a vasopressin receptor-deficient mice.

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The cloning of the rat kidney V2 AVP receptor complementary DNA that encodes a 370-amino-acid protein with a transmembrane topography characteristic of G protein-coupled receptors, and with similarity to the Via (hepatic) AVP receptors2 in its seven membrane-spanning domains is reported.

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An indispensable role for renin is demonstrated in the circulating angiotensin generation and in the maintenance of blood pressure, but a dispensable role forrenin in the blood-brain barrier function is suggested.