Vasopressin modulation of peritoneal, lymphatic, and plasma drug exposure following intraperitoneal administration.

@article{Lindnr1996VasopressinMO,
  title={Vasopressin modulation of peritoneal, lymphatic, and plasma drug exposure following intraperitoneal administration.},
  author={Per Lindn{\'e}r and Deborah Heath and Stuart Howell and P Naredi and Lo Hafstr{\"o}m},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={1996},
  volume={2 2},
  pages={311-7}
}
i.p. administration of cytotoxic drugs for the treatment of regionally confined cancers results in a greater total drug exposure [area under the concentration x time curve (AUC)] for the peritoneal fluid and regional lymphatics than for plasma. We sought to augment the relative advantage of i.p. administration further through modulation of peritoneal clearance by reduction in splanchnic blood flow. Pigs were treated with 5-fluorouracil, etoposide (VP-16), and carboplatin (CBDCA) alone by the i… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 16 references

Intraperitoneal chemotherapy: principles and results of clinical trials

M. Markman, S. B. Howell
1987

Similar Papers

Loading similar papers…