Vasopressin-independent targeting of aquaporin-2 by selective E-prostanoid receptor agonists alleviates nephrogenic diabetes insipidus.

@article{Olesen2011VasopressinindependentTO,
  title={Vasopressin-independent targeting of aquaporin-2 by selective E-prostanoid receptor agonists alleviates nephrogenic diabetes insipidus.},
  author={Emma T. B. Olesen and Michael R{\"u}tzler and Hanne B. Moeller and Helle A Praetorius and Robert Andrew Fenton},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 31},
  pages={12949-54}
}
In the kidney, the actions of vasopressin on its type-2 receptor (V2R) induce increased water reabsorption alongside polyphosphorylation and membrane targeting of the water channel aquaporin-2 (AQP2). Loss-of-function mutations in the V2R cause X-linked nephrogenic diabetes insipidus. Treatment of this condition would require bypassing the V2R to increase AQP2 membrane targeting, but currently no specific pharmacological therapy is available. The present study examined specific E-prostanoid… CONTINUE READING
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Quantitative analysis of aquaporin-2 phosphorylation

  • L Xie
  • Am J Physiol Renal Physiol 298:F1018–F1023
  • 2010
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