Vasopressin as a target for antidepressant development: an assessment of the available evidence.

@article{Scott2002VasopressinAA,
  title={Vasopressin as a target for antidepressant development: an assessment of the available evidence.},
  author={Lucinda V Scott and Timothy G Dinan},
  journal={Journal of affective disorders},
  year={2002},
  volume={72 2},
  pages={113-24}
}
Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis is one of the key biological abnormalities described in major depressive disorder, occurring in 30-50% of depressed subjects. Corticotropin-releasing hormone (CRH) and vasopressin (AVP) are the main regulators of this stress system, with the two neuropeptides acting synergistically in bringing about adrenocorticotropin (ACTH) release from the anterior pituitary and cortisol from the adrenal gland. Based on the demonstration of… CONTINUE READING
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