Vasopressin antagonists as aquaretic agents for the treatment of hyponatremia.

  title={Vasopressin antagonists as aquaretic agents for the treatment of hyponatremia.},
  author={Catrin Palm and Frank Pistrosch and Kay Herbrig and Peter Gross},
  journal={The American journal of medicine},
  volume={119 7 Suppl 1},
Hyponatremia is the most frequent electrolyte disorder encountered in hospitalized patients. It is a state of relative water excess due to stimulated arginine vasopressin (AVP) and fluid intake greater than obligatory losses. This kind of hyponatremia occurs in the syndrome of inappropriate antidiuretic hormone secretion, congestive heart failure, and liver cirrhosis. Fluid restriction is the presently recommended treatment for hyponatremia. However, fluid restriction may be very difficult for… CONTINUE READING


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