Vasopressin antagonism in heart failure.

  title={Vasopressin antagonism in heart failure.},
  author={Steven Goldsmith and Mihai Gheorghiade},
  journal={Journal of the American College of Cardiology},
  volume={46 10},
Treatment of chronic heart failure (HF) is based on interference with the renin-angiotensin-aldosterone system and the adrenergic nervous system. Diuretics are used in volume-expanded patients. Insights from clinical trials and registries establish the need to consider correcting both cardiac loading conditions and nonload-related biological factors if HF therapy is to be optimized. Arginine vasopressin (AVP) represents a potentially attractive target for therapy in both acute and chronic HF… CONTINUE READING
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