Vasopressin V1A receptors mediate the stabilization of intestinal mucosal oxygenation during hypercapnia in septic rats.

@article{Schneborn2016VasopressinVR,
  title={Vasopressin V1A receptors mediate the stabilization of intestinal mucosal oxygenation during hypercapnia in septic rats.},
  author={Sabrina Sch{\"o}neborn and Christian Vollmer and Franziska Barthel and A. G. Herminghaus and Jan Schulz and Isabella Bauer and Christopher P. Beck and Olaf Picker},
  journal={Microvascular research},
  year={2016},
  volume={106},
  pages={
          24-30
        }
}
BACKGROUND Microvascular oxygen saturation (μHBO2) plays an essential role in the development and outcome of sepsis. Hypercapnia (HC) improves the microvascular oxygenation of the mucosa in both healthy and septic animals. Vasopressin V1A receptor blockade prevents this positive effect under otherwise physiological conditions. The aim of this study was to investigate the effects and mechanisms of the vasopressin system during hypercapnia under septic conditions. METHODS 80 rats were… CONTINUE READING
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