Vasopressin V(2)-receptor-dependent regulation of AQP2 expression in Brattleboro rats.

@article{Promeneur2000VasopressinVR,
  title={Vasopressin V(2)-receptor-dependent regulation of AQP2 expression in Brattleboro rats.},
  author={Dominique Promeneur and T H Kwon and J\orgen Fr\okiaer and Mark A. Knepper and S\oren Lyhne Nielsen},
  journal={American journal of physiology. Renal physiology},
  year={2000},
  volume={279 2},
  pages={F370-82}
}
The role of AVP-V(2) receptor (AVP-V(2)R)-dependent regulation of aquaporin-2 (AQP2) expression was evaluated in vasopressin-deficient Brattleboro (BB) rats. AQP2 levels were relatively high in BB rats (52 +/- 8% of levels in Wistar rats), and treatment with the AVP-V(2)R antagonist SR-121463A (0.8 mg/day) for 48 h was associated with 1) increased urine output (170 +/- 9%), 2), reduced AQP2 protein levels (42 +/- 10% in whole kidney and 53 +/- 8% in inner medulla), and 3) reduced AQP2 mRNA… CONTINUE READING

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Altered expression of renal aquaporins and Na1-transporters in rats with lithiuminduced nephrogenic diabetes insipidus (Abstract)

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