Vasopressin Mediates the Response of the Combined Dexamethasone/CRH Test in Hyper-anxious Rats: Implications for Pathogenesis of Affective Disorders

@article{Keck2002VasopressinMT,
  title={Vasopressin Mediates the Response of the Combined Dexamethasone/CRH Test in Hyper-anxious Rats: Implications for Pathogenesis of Affective Disorders},
  author={Martin E. Keck and Alexandra Wigger and Tobias Welt and Marianne B Muller and Angela Gesing and Johannes M. H. M. Reul and Florian Holsboer and Rainer Landgraf and Inga D. Neumann},
  journal={Neuropsychopharmacology},
  year={2002},
  volume={26},
  pages={94-105}
}
To investigate the neuroendocrine alterations linked to inborn emotionality in two Wistar rat lines selectively bred for either high (HAB) or low (LAB) anxiety-related behavior, we administered the combined dexamethasone (DEX)/corticotropin-releasing hormone (CRH) test. DEX (12:00 M. (noon); 30 μg/kg) resulted in a significantly less efficient suppression of the diurnal increase in the circulating corticotropin (ACTH) levels in the male HAB rats than in the male LAB rats. In addition, plasma… CONTINUE READING
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