Vasopressin: a new target for the treatment of heart failure.

  title={Vasopressin: a new target for the treatment of heart failure.},
  author={Craig R. Lee and Michael L. Watkins and James H. Patterson and Wendy A. Gattis and Christopher M. O'Connor and Mihai Gheorghiade and Kirkwood F. Adams},
  journal={American heart journal},
  volume={146 1},
BACKGROUND Arginine vasopressin is a peptide hormone that modulates a number of processes implicated in the pathogenesis of heart failure. Numerous vasopressin antagonists are currently under development for the treatment of this syndrome. METHODS Preclinical and clinical data describing the effects of vasopressin and the vasopressin antagonists on both normal physiology and heart failure were reviewed. RESULTS Through activation of V(1a) and V(2) receptors, vasopressin regulates various… CONTINUE READING
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