Vasopressin: a model for the study of effects of additives on the oral and rectal administration of peptide drugs.

Abstract

We previously observed, using a relatively primitive assay, that small oral doses (on the order of 1 microgram = 1 nmol = 1000 pmol per rat) of vasopressin can produce antidiuresis in hydrated rats, and that the oral activity was enhanced by simultaneous administration of an inhibitor of intestinal proteolysis. A more sensitive semi-automated computer… (More)

Topics

Cite this paper

@article{Saffran1988VasopressinAM, title={Vasopressin: a model for the study of effects of additives on the oral and rectal administration of peptide drugs.}, author={Murray Saffran and C Bedra and G. S. Kumar and Douglas C. Neckers}, journal={Journal of pharmaceutical sciences}, year={1988}, volume={77 1}, pages={33-8} }