Vasopeptidase inhibitor ilepatril (AVE7688) prevents obesity- and diabetes-induced neuropathy in C57Bl/6J mice.

@article{Coppey2011VasopeptidaseII,
  title={Vasopeptidase inhibitor ilepatril (AVE7688) prevents obesity- and diabetes-induced neuropathy in C57Bl/6J mice.},
  author={Lawrence J. Coppey and Eric P. Davidson and Bao Shi Lu and Craig Gerard and Mark A Yorek},
  journal={Neuropharmacology},
  year={2011},
  volume={60 2-3},
  pages={259-66}
}
Previously we demonstrated that inhibition of neutral endopeptidase (NEP), a protease that degrades vaso- and neuro-active peptides, and angiotensin converting enzyme (ACE) with a vasopeptidase inhibitor improves vascular and neural function in diabetic rat models. The purpose of this study was to determine whether inhibition of NEP and ACE or deletion of NEP provides protection from nerve impairment caused by diabetes or diet induced obesity (DIO). To determine the role of NEP and ACE… CONTINUE READING

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