Vasoinhibitory effect of NP-252, a new dihydropyridine derivative, in canine cerebral artery.

Abstract

The vasoinhibitory effect of NP-252, a 1,4-dihydropyridine derivative Ca++ antagonist, was examined in canine cerebral artery, and this effect was compared with that of nifedipine. NP-252 (10(-7)M) and nifedipine (10(-6) M) nearly abolished the contraction induced by addition of Ca++ to Ca(++)-free medium containing KC1. NP-252 (10(-6)M) and nifedipine (10… (More)

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Cite this paper

@article{Akimoto1991VasoinhibitoryEO, title={Vasoinhibitory effect of NP-252, a new dihydropyridine derivative, in canine cerebral artery.}, author={Y. Akimoto and Kazuyoshi Kurahashi and H. Usui and Masayuki Fujiwara}, journal={Life sciences}, year={1991}, volume={48 2}, pages={183-8} }