Vasodilatory N-methyl-D-aspartate receptors are constitutively expressed in rat kidney.

@article{Deng2002VasodilatoryNR,
  title={Vasodilatory N-methyl-D-aspartate receptors are constitutively expressed in rat kidney.},
  author={Aihua Deng and Jos{\'e} M Valdivielso and Karen A. Munger and Roland C. Blantz and Scott Culver Thomson},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2002},
  volume={13 5},
  pages={
          1381-4
        }
}
N-methyl-D-aspartate receptor (NMDA-R) is an amino acid receptor and membrane calcium channel. NMDA-R is activated by binding of coagonists, L-glutamine and L-glycine. In the brain, calcium entry via NMDA-R activates type I nitric oxide synthase (NOS I). The kidney also contains NOS I and vasodilates in response to L-glycine. In this study, NMDA-R mRNA was demonstrated in rat kidney cortex by reverse transcriptase-PCR and cDNA sequencing. NMDA-R protein was demonstrated in kidney cortex by… CONTINUE READING

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