Vasodilator actions of HA1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase.

@article{Asano1989VasodilatorAO,
  title={Vasodilator actions of HA1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase.},
  author={Toshio Asano and Tomoyuki Suzuki and Megumi Tsuchiya and Shin ichi Satoh and Ichiro Ikegaki and Masato Shibuya and Yoshikatsu Suzuki and Hiroyoshi Hidaka},
  journal={British journal of pharmacology},
  year={1989},
  volume={98 4},
  pages={
          1091-100
        }
}
  • Toshio Asano, Tomoyuki Suzuki, +5 authors Hiroyoshi Hidaka
  • Published in
    British journal of…
    1989
  • Chemistry, Medicine
  • The in vitro and in vivo vasorelaxant effects of HA1077, 1-(5-isoquinolinesulphonyl)-homopiperazine HCl, a novel vasodilator were examined. The inhibitory effects of HA1077 on contractile responses to various agonists were examined on strips of rabbit aorta. The concentration-response curves to 5-hydroxytryptamine, prostaglandin F2alpha, histamine, angiotensin II, noradrenaline and dopamine were concentration-dependently shifted to the right in the presence of HA1077 (0.3-3.0 microM). The in… CONTINUE READING

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