Vasodilation induced by substance P in guinea pig carotid arteries.

@article{Zhang1994VasodilationIB,
  title={Vasodilation induced by substance P in guinea pig carotid arteries.},
  author={Guoliang Zhang and Yoshimichi Yamamoto and Kiyoshi Miwa and Hikaru Suzuki},
  journal={The American journal of physiology},
  year={1994},
  volume={266 3 Pt 2},
  pages={H1132-7}
}
In the guinea pig carotid artery with an intact endothelium, substance P (SP, 10(-10)-10(-7) M) relaxed the norepinephrine- (NE) contracted smooth muscles transiently, in a concentration-dependent manner. Acetylcholine (ACh, 10(-6) M) produced a sustained relaxation. SP and ACh also relaxed muscles contracted with high-K (29.6 mM) solution, with a similar… CONTINUE READING