Vasodilating effects of human and rat calcitonin gene-related peptides in isolated porcine coronary arteries

@article{Shoji1987VasodilatingEO,
  title={Vasodilating effects of human and rat calcitonin gene-related peptides in isolated porcine coronary arteries},
  author={Tetsuo Shoji and I. Ishihara and Tsutomu Ishikawa and Akira Saito and Kashima Goto},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1987},
  volume={336},
  pages={438-444}
}
Human and rat α-calcitonin gene-related peptides (CGRPs) caused relaxation of porcine coronary arterial strips precontracted by 10−5 M of prostaglandin (PG) F2α at low concentrations. pD2 values for human and rat CGRPs in endothelium-preserved strips were 8.41 ± 0.03 (n = 5) and 8.49 ± 0.03 (n = 5), respectively. The same concentrations of CGRPs relaxed the endothelium-depleted preparations. CGRPs were much more potent and had steeper concentration-response curves than isoproterenol… CONTINUE READING

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