Vasodilatation of small and large arteries in hypertension.

  title={Vasodilatation of small and large arteries in hypertension.},
  author={Jaime A. Levenson and Alain C. Simon and Michel E. Safar},
  journal={Journal of cardiovascular pharmacology},
  volume={7 Suppl 2},
In patients with essential hypertension, vasodilating antihypertensive drugs act differently on small and large arteries. For similar blood pressure reductions, the diameter of the brachial artery may be unchanged (alpha- and beta-blocking drugs), decreased (dihydralazine), or increased (nitrates, renin-angiotensin and calcium-entry inhibitors). Increase in blood flow is due preferentially to an increase in blood flow velocity and is caused additionally by an increase in the diameter of the… CONTINUE READING


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