Vasoconstriction in human isolated middle meningeal arteries: determining the contribution of 5-HT1B- and 5-HT1F-receptor activation.

@article{Razzaque1999VasoconstrictionIH,
  title={Vasoconstriction in human isolated middle meningeal arteries: determining the contribution of 5-HT1B- and 5-HT1F-receptor activation.},
  author={Z. Razzaque and Mark A. Heald and J. D. Pickard and Lesley Maskell and Margaret S. Beer and Raymond G Hill and Jane Longmore},
  journal={British journal of clinical pharmacology},
  year={1999},
  volume={47 1},
  pages={
          75-82
        }
}
AIMS Sumatriptan is a 5-HT1B/1D-receptor agonist which also has affinity for 5-HT1F-receptors. The vasoconstrictor effects of sumatriptan are thought to be 5-HT1B-receptor mediated and these receptors have been shown to be expressed in human cranial blood vessels. However, in the same tissue mRNA coding for 5-HT1F-receptors has also been identified and this study addresses the possibility of whether 5-HT1F-receptor activation contributes to vasoconstriction. METHODS The ability of two… CONTINUE READING

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