Vasoactive peptide release in the extracerebral circulation of humans during migraine headache

@article{Goadsby1990VasoactivePR,
  title={Vasoactive peptide release in the extracerebral circulation of humans during migraine headache},
  author={Peter J. Goadsby and Lars Edvinsson and Rolf Ekman},
  journal={Annals of Neurology},
  year={1990},
  volume={28}
}
The innervation of the cranial vessels by the trigeminal nerve, the trigeminovascular system, has recently been the subject of study in view of its possible role in the mediation of some aspects of migraine. Since stimulation of the trigeminal ganglion in humans leads to facial pain and flushing and associated release of powerful neuropeptide vasodilator substances, their local release into the extracerebral circulation of humans was determined in patients who had either common or classic… 
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1,353 Citations

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Migraine and neuropeptides

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Correlation between CGRP and Migraine Attacks

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  • Medicine
    Cephalalgia : an international journal of headache
  • 2005
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It is demonstrated that sumatriptan decreases the plasma CGRP concentration in the antecubital vein during migraine attacks elicited by nitroglycerin administration, and this decrease was present only in those patients whose headache showed parallel clinical improvement.

Reduction of Calcitonin Gene-Related Peptide in Jugular Blood Following Electrical Stimulation of Rat Greater Occipital Nerve

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It is proposed that stimulation of the rat GON inhibits the trigeminal system (reduction of CGRP-LI) and possibly activates parasympathetic fibres (ocular changes).

Neuropeptide effects in the trigeminal system: pathophysiology and clinical relevance in migraine.

TLDR
The currently available data indicate multiple sites of CGRP action in trigeminal nociception and the pathogenesis of migraine; however, central C GRP receptors are likely to be the essential targets in the treatment of migraine using CgrP receptor antagonists.

Sumatriptan Reverses the Changes in Calcitonin Gene-Related Peptide Seen in the Headache Phase of Migraine

TLDR
The effect of parentral administration of sumatriptan on neuropeptide levels in the cranial vessels during migraine is examined.

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Results show that VIP causes a decrease in VmeanMCA without affecting rCBF, and in spite of a marked vasodilator effect in the extracranial vessels and increased plasma VIP, healthy subjects developed only a very mild headache.

Regulation of meningeal blood flow by neuropeptides: Relevance to migraine

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The neurogenic inflammation of the meninges in particular (an experimental inflammation characterized by oedema, hyperaemia, activation of platelets, endothelium and mast cells following antidromic stimulation of trigeminal afferents) has attracted the attention of several investigators.
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References

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TLDR
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TLDR
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TLDR
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