Vasoactive peptide release in the extracerebral circulation of humans during migraine headache

  title={Vasoactive peptide release in the extracerebral circulation of humans during migraine headache},
  author={Peter J. Goadsby and Lars Edvinsson and Rolf Ekman},
  journal={Annals of Neurology},
The innervation of the cranial vessels by the trigeminal nerve, the trigeminovascular system, has recently been the subject of study in view of its possible role in the mediation of some aspects of migraine. Since stimulation of the trigeminal ganglion in humans leads to facial pain and flushing and associated release of powerful neuropeptide vasodilator substances, their local release into the extracerebral circulation of humans was determined in patients who had either common or classic… 

The trigeminovascular system and migraine: Studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats

These data characterize some aspects of the cerebrovascular physiology of the trigeminovascular system and demonstrate important interactions between this system and the effective antimigraine agents sumatriptan and dihydroergotamine and that such interactions can be represented in animal models.

Absence of Vasoactive Peptide Release from Brain to Cerebral Circulation During Onset of Migraine With Aura

The overall plasma levels of the potent vasoconstrictor NPY were higher in the group that developed symptoms and rCBF changes than in the non-symptomatic group, and the difference in NPY levels could perhaps be associated with the focal r CBF decrease seen in the attack group.

Migraine and neuropeptides

[Neuropeptide effects on the trigeminal system: pathophysiology and clinical significance for migraine].

The currently available data indicate multiple sites of CGRP action in trigeminal nociception and the pathogenesis of migraine but central C GRP receptors are probably the essential targets in the treatment of migraine using CGRp receptor antagonists.

Correlation between CGRP and Migraine Attacks

  • L. Edvinsson
  • Medicine
    Cephalalgia : an international journal of headache
  • 2005
It is demonstrated that sumatriptan decreases the plasma CGRP concentration in the antecubital vein during migraine attacks elicited by nitroglycerin administration, and this decrease was present only in those patients whose headache showed parallel clinical improvement.

Reduction of Calcitonin Gene-Related Peptide in Jugular Blood Following Electrical Stimulation of Rat Greater Occipital Nerve

It is proposed that stimulation of the rat GON inhibits the trigeminal system (reduction of CGRP-LI) and possibly activates parasympathetic fibres (ocular changes).

Neuropeptide effects in the trigeminal system: pathophysiology and clinical relevance in migraine.

The currently available data indicate multiple sites of CGRP action in trigeminal nociception and the pathogenesis of migraine; however, central C GRP receptors are likely to be the essential targets in the treatment of migraine using CgrP receptor antagonists.

Sumatriptan Reverses the Changes in Calcitonin Gene-Related Peptide Seen in the Headache Phase of Migraine

The effect of parentral administration of sumatriptan on neuropeptide levels in the cranial vessels during migraine is examined.

Vasoactive Intestinal Polypeptide Evokes Only a Minimal Headache in Healthy Volunteers

Results show that VIP causes a decrease in VmeanMCA without affecting rCBF, and in spite of a marked vasodilator effect in the extracranial vessels and increased plasma VIP, healthy subjects developed only a very mild headache.

Regulation of meningeal blood flow by neuropeptides: Relevance to migraine

The neurogenic inflammation of the meninges in particular (an experimental inflammation characterized by oedema, hyperaemia, activation of platelets, endothelium and mast cells following antidromic stimulation of trigeminal afferents) has attracted the attention of several investigators.



Release of vasoactive peptides in the extracerebral circulation of humans and the cat during activation of the trigeminovascular system

The observation of elevation of substance P—like and CGRP‐like immunoreactivity after activation of the nociceptive afferent system of the head provides new insights into a putative role of peptides in the pathophysiology of migraine and cluster headache, and suggests new areas of possible therapeutic intervention.

Facial Temperature in Migraine, Tension-Vascular and Tension Headache

  • P. DrummondJ. Lance
  • Medicine, Psychology
    Cephalalgia : an international journal of headache
  • 1984
It was concluded that extracranial vascular changes recur intermittently in headache-prone patients, depending on the severity of pain and association with other features commonly regarded as migrainous, and there was no clear demarcation point between entities diagnosed clinically as “migraine” and “tension headache”.

Circulating perivascular dilatory neuropeptides in hypertension.

Observations suggest that vascular afferent nerves play a part in the maintenance of hypertension.

Decreased carotid arterial resistance in cats in response to trigeminal stimulation.

It is concluded that activation of the trigeminal system increases carotid blood flow by a pathway involving the seventh cranial nerve, the GSP and Vidian nerves, and a parasympathetic synapse employing an unconventional transmitter.

Characterization of 5‐hydroxytryptamine receptors in human temporal arteries: Comparison between migraine sufferers and nonsufferers

Clear evidence has been obtained demonstrating the presence of 5‐HT receptors in human temporal arteries, although the authors could observe no difference in the character of the 5‐ HT receptros between migraine patients and controls.