Vasoactive peptide release in the extracerebral circulation of humans during migraine headache

@article{Goadsby1990VasoactivePR,
  title={Vasoactive peptide release in the extracerebral circulation of humans during migraine headache},
  author={P. J. Goadsby and L. Edvinsson and R. Ekman},
  journal={Annals of Neurology},
  year={1990},
  volume={28}
}
  • P. J. Goadsby, L. Edvinsson, R. Ekman
  • Published 1990
  • Medicine
  • Annals of Neurology
    • The innervation of the cranial vessels by the trigeminal nerve, the trigeminovascular system, has recently been the subject of study in view of its possible role in the mediation of some aspects of migraine. Since stimulation of the trigeminal ganglion in humans leads to facial pain and flushing and associated release of powerful neuropeptide vasodilator substances, their local release into the extracerebral circulation of humans was determined in patients who had either common or classic… CONTINUE READING
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    References

    SHOWING 1-10 OF 26 REFERENCES
    Release of vasoactive peptides in the extracerebral circulation of humans and the cat during activation of the trigeminovascular system
    • 724
    NEUROTRANSMITTERS AND THE FIFTH CRANIAL NERVE: IS THERE A RELATION TO THE HEADACHE PHASE OF MIGRAINE?
    • 181
    Innervation of the feline cerebral vasculature by nerve fibers containing calcitonin gene-related peptide: Trigeminal origin and co-existence with substance P
    • 373
    Facial Temperature in Migraine, Tension-Vascular and Tension Headache
    • 51
    Stimulation of the Trigeminal ganglion increases flow in the extracerebral but not the cerebral circulation of the monkey
    • 71
    Circulating perivascular dilatory neuropeptides in hypertension.
    • 8
    Neurokinin A in cerebral vessels: characterization, localization and effects in vitro
    • 95
    Decreased carotid arterial resistance in cats in response to trigeminal stimulation.
    • 160
    • PDF
    Extracranial vasodilatation mediated by vasoactive intestinal polypeptide (VIP)
    • 92
    Characterization of 5‐hydroxytryptamine receptors in human temporal arteries: Comparison between migraine sufferers and nonsufferers
    • 25