Vasoactive peptide release in the extracerebral circulation of humans during migraine headache

  title={Vasoactive peptide release in the extracerebral circulation of humans during migraine headache},
  author={P. J. Goadsby and L. Edvinsson and R. Ekman},
  journal={Annals of Neurology},
  • P. J. Goadsby, L. Edvinsson, R. Ekman
  • Published 1990
  • Medicine
  • Annals of Neurology
  • The innervation of the cranial vessels by the trigeminal nerve, the trigeminovascular system, has recently been the subject of study in view of its possible role in the mediation of some aspects of migraine. Since stimulation of the trigeminal ganglion in humans leads to facial pain and flushing and associated release of powerful neuropeptide vasodilator substances, their local release into the extracerebral circulation of humans was determined in patients who had either common or classic… CONTINUE READING
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