Vasoactive peptide release in the extracerebral circulation of humans during migraine headache

@article{Goadsby1990VasoactivePR,
  title={Vasoactive peptide release in the extracerebral circulation of humans during migraine headache},
  author={Peter J. Goadsby and Lars Edvinsson and Rolf Ekman},
  journal={Annals of Neurology},
  year={1990},
  volume={28}
}
The innervation of the cranial vessels by the trigeminal nerve, the trigeminovascular system, has recently been the subject of study in view of its possible role in the mediation of some aspects of migraine. Since stimulation of the trigeminal ganglion in humans leads to facial pain and flushing and associated release of powerful neuropeptide vasodilator substances, their local release into the extracerebral circulation of humans was determined in patients who had either common or classic… 
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  • 2005
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Reduction of Calcitonin Gene-Related Peptide in Jugular Blood Following Electrical Stimulation of Rat Greater Occipital Nerve

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The currently available data indicate multiple sites of CGRP action in trigeminal nociception and the pathogenesis of migraine; however, central C GRP receptors are likely to be the essential targets in the treatment of migraine using CgrP receptor antagonists.

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Vasoactive Intestinal Polypeptide Evokes Only a Minimal Headache in Healthy Volunteers

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Regulation of meningeal blood flow by neuropeptides: Relevance to migraine

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References

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  • 1984
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