Vasoactive intestinal polypeptide presynaptically enhances the synaptic transmission in cultured sympathetic neurons.

Abstract

We studied the effects of vasoactive intestinal polypeptide (VIP) on the cholinergic synaptic transmission that was developed between rat sympathetic neurons in culture. Electrophysiological examinations revealed that the amplitude of fast excitatory postsynaptic potential (fast EPSP) was increased by VIP (0.2-0.8 microM) reversibly and dose-dependently… (More)

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