Vasoactive intestinal polypeptide modulation of nicotinic ACh receptor channels in rat intracardiac neurones.

@article{Cuevas1996VasoactiveIP,
  title={Vasoactive intestinal polypeptide modulation of nicotinic ACh receptor channels in rat intracardiac neurones.},
  author={Javier Marcos Cuevas and David J Adams},
  journal={The Journal of physiology},
  year={1996},
  volume={493 ( Pt 2)},
  pages={503-15}
}
1. The effects of vasoactive intestinal polypeptide (VIP) on isolated parasympathetic neurones of rat intracardiac ganglia were examined under voltage clamp using dialysed and perforated patch whole-cell and excised outside-out membrane patch recording configurations. 2. VIP reversibly potentiated nicotinic ACh-evoked whole-cell currents, with half-maximal potentiation (EC50) obtained with 260 pM VIP. However, VIP had no effect on muscarinic ACh-evoked currents, ATP-evoked currents, or… CONTINUE READING
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