Vasoactive intestinal polypeptide in cholinergic neurons of exocrine glands: functional significance of coexisting transmitters for vasodilation and secretion.

@article{Lundberg1980VasoactiveIP,
  title={Vasoactive intestinal polypeptide in cholinergic neurons of exocrine glands: functional significance of coexisting transmitters for vasodilation and secretion.},
  author={Jan M. Lundberg and Anders Angg{\aa}rd and Jan Fahrenkrug and Tomas G M H{\"o}kfelt and Viktor Mutt},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1980},
  volume={77 3},
  pages={1651-5}
}
By a combination of the indirect immunofluorescence technique with acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7) staining, it was shown that vasoactive intestinal polypeptide (VIP) is present in cholinergic (acetylcholinesterase-rich) neurons involved in control of secretion and vasodilation in exocrine glands of cat. The submandibular salivary gland was used as a functional model. Preganglionic nerve stimulation induced an atropine-resistant, hexamethonium-sensitive… CONTINUE READING

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