Vasoactive intestinal peptide potentiates sexual behavior: inhibition by novel antagonist.

@article{Gozes1989VasoactiveIP,
  title={Vasoactive intestinal peptide potentiates sexual behavior: inhibition by novel antagonist.},
  author={Illana Gozes and Eyal Meltzer and S Rubinrout and Douglas E. Brenneman and Mati Fridkin},
  journal={Endocrinology},
  year={1989},
  volume={125 6},
  pages={2945-9}
}
Vasoactive intestinal peptide (VIP) has been suggested as a neurotransmitter mediating penile erection. We now show that VIP can stimulate sexual behavior in rats with reduced masculine potential due to pituitary grafting or castration. This effect was attenuated in the presence of a novel VIP antagonist, devised by a hybrid peptide strategy. Thus, we have synthesized a molecule combining a portion of VIP with a portion of neurotensin, peptides of opposite pharmacological action on cAMP… CONTINUE READING

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