Vasoactive intestinal peptide induces regulatory dendritic cells that prevent acute graft-versus-host disease while maintaining the graft-versus-tumor response.

@article{Chorny2006VasoactiveIP,
  title={Vasoactive intestinal peptide induces regulatory dendritic cells that prevent acute graft-versus-host disease while maintaining the graft-versus-tumor response.},
  author={Alejo Chorny and Elena Gonz{\'a}lez-Rey and Amelia Fernandez-Martin and Doina Ganea and Mario Delgado},
  journal={Blood},
  year={2006},
  volume={107 9},
  pages={3787-94}
}
Acute graft-versus-host disease (GVHD) is a major cause of morbidity and mortality in patients undergoing allogeneic bone marrow transplantation (BMT) for the treatment of leukemia and other immunogenetic disorders. The use of tolerogenic dendritic cells (DCs) that induce the generation/activation of regulatory T (Tr) cells for the treatment of acute GVHD… CONTINUE READING