Vasoactive intestinal peptide in thymus: synthesis, receptors and biological actions.

@article{Delgado1999VasoactiveIP,
  title={Vasoactive intestinal peptide in thymus: synthesis, receptors and biological actions.},
  author={M J Santos Delgado and Carmen Mart{\'i}nez and Javier Leceta and Rosa P Gomariz},
  journal={Neuroimmunomodulation},
  year={1999},
  volume={6 1-2},
  pages={97-107}
}
Evidence summarized in this report indicates that thymocytes produce and secrete VIP. Moreover, different stimuli such as Con A, LPS and anti-TCR antibody induce a significant increase in VIP production by thymocytes. In addition, proinflammatory cytokines such as IL-1, IL-6 and TNF-alpha, but not IL-2, stimulate in a similar time-dependent manner VIP production by lymphocytes. We also describe the expression of VIP1 receptor and VIP2 receptor mRNA in murine thymocytes. Thus, VIP released in… CONTINUE READING