Vasoactive intestinal peptide in human nasal mucosa.

@article{Baraniuk1990VasoactiveIP,
  title={Vasoactive intestinal peptide in human nasal mucosa.},
  author={James N. Baraniuk and Jens D. Lundgren and M Okayama and Joaquim Mullol and Marco Merida and James H. Shelhamer and Michael A. Kaliner},
  journal={The Journal of clinical investigation},
  year={1990},
  volume={86 3},
  pages={
          825-31
        }
}
Vasoactive intestinal peptide (VIP), which is present with acetylcholine in parasympathetic nerve fibers, may have important regulatory functions in mucous membranes. The potential roles for VIP in human nasal mucosa were studied using an integrated approach. The VIP content of human nasal mucosa was determined to be 2.84 +/- 0.47 pmol/g wet weight (n = 8) by RIA. VIP-immunoreactive nerve fibers were found to be most concentrated in submucosal glands adjacent to serous and mucous cells. 125I… 
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Endothelin in human nasal mucosa.
TLDR
The observations indicate that in the human nasal mucosa, ET is present in the vascular endothelium and the serous cells in submucosal glands and acts on glandular ET receptors to induce both serous and mucous cell secretion.
Vasoactive intestinal peptide stimulates apical secretion in hamster seminal vesicle epithelial cells in culture
TLDR
The results of this work indicate that VIP receptors are present in the membranes of clusters of epithelial cells from seminal vesicles and are further maintained in cultured cells, and VIP affects the directionality of secretion, favouring the absolute and relative amounts of protein released to the apical compartment of the bi-chamber.
Alterations of Vasoactive Intestinal Polypeptide Receptors in Allergic Rhinitis
TLDR
The results suggest that an increased expression level of VIP receptors is one possible explanation for nasal hyperresponsiveness in patients with allergic rhinitis.
Endothelin-1 stimulates eicosanoid production in cultured human nasal mucosa.
TLDR
It is concluded that ET-1 induces the release of predominantly cyclooxygenase products from cultured human nasal mucosal explants.
Expression of vasoactive intestinal peptide, calcitonin gene-related peptide, substance P, and intermediate neurofilaments in nasal mucosal nerve fibers of horses without nasal disease.
TLDR
The density and distribution of nerve fibers containing SP- or CGRP-Li in nasal mucosa of horses was similar to that reported for other species, however, expression of VIP in nerve fibers was low.
Endothelin in nasal mucosa: role in nasal function and inflammation
  • Mullol, Picado
  • Medicine, Biology
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2000
TLDR
A role for ET in nasal polyposis and rhinitis has been suggested, and ET-induced cytokine release could contribute to chemoattraction of pro-in ́ammatory cells such as eosinophils, neutrophils, B cells and T cells, which could in turn contribute to the perpetuation of nasal in ̄ammation.
Vasoactive intestinal polypeptide as mediator of asthma.
TLDR
Although a therapy using the strong bronchodilatory effects of VIP would offer potential benefits, the rapid inactivation of the peptide by airway peptidases has prevented effective VIP-based drugs so far and non-peptide VIP-agonists did not reach clinical use.
The effects of neuropeptides on mucous glycoprotein secretion from human nasal mucosa in vitro
Functional effects of phosphoramidon and captopril on exogenous neuropeptides in human nasal mucosa
TLDR
Since these neuropeptides induced nasal obstruction, increased blood flow and rhinorrhea, a decreased activity of the enzymes involved in their degradation could be involved in the physiopathology of rhinitis symptoms.
Neuropeptide regulation of secretion and inflammation in human airway gland serous cells
TLDR
VIP and NPY are neuropeptides up-regulated in allergy and asthma, respectively, which inversely regulate CFTR-dependent secretion and inflammation in airway submucosal gland serous cells, and which secrete much of the fluid that lines conducting airways.
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References

SHOWING 1-10 OF 51 REFERENCES
Inhibition by vasoactive intestinal peptide of glycoconjugate and lysozyme secretion by human airways in vitro.
TLDR
The hypothesis that VIP may contribute to the neurohumoral regulation of mucus secretion by the human airway is supported, however, it was evident that the effects of VIP could not be accounted for in terms of inhibiting cell discharge alone.
Neuropeptide Y (NPY) in human nasal mucosa.
TLDR
Neuropeptide Y released from sympathetic neurons may play a role as a constrictor of arterial vessels and regulate vasomotor tone in the human nasal mucosa.
cAMP immunocytochemistry provides evidence for functional VIP receptors in trachea.
TLDR
It is concluded that ferret tracheal epithelium and dog epithelial goblet cells showed little or no reactivity after VIP, and thus it is believed that these cells lack VIP receptors, and therefore participate in VIP-stimulated responses.
Vasoactive intestinal peptide stimulates tracheal submucosal gland secretion in ferret.
TLDR
It is concluded that VIP stimulates output of sulfated-macromolecules from ferret tracheal submucosal glands without stimulating ion transport, and this mechanism may be important in the neural regulation of sub mucosal gland secretion.
VIP augments cholinergic-induced glycoconjugate secretion in tracheal submucosal glands.
TLDR
Results indicate that VIP induces mucus glycoprotein release from secretory cells and also that it potentiates the secretion induced by cholinergic stimulation.
Vasoactive peptides in the lung, with special reference to vasoactive intestinal peptide.
  • S. Said
  • Biology
    Experimental lung research
  • 1982
TLDR
One of these peptides, VIP, widely distributed in other organ systems, may mediate the nonadrenergic relaxation of airways and pulmonary vessels and may modulate the immunologic release of mediators from mast cells.
Complementary role of vasoactive intestinal polypeptide (VIP) and acetylcholine for cat submandibular gland blood flow and secretion.
TLDR
The present findings suggest that the secretory and vasodilatory responses may be caused by an interaction between these two agents.
Visualization of vasoactive intestinal peptide receptors in human and guinea pig lung.
TLDR
In both human and guinea pig lung there was labeling of cellular structures and no specific labeling pattern was found in sections incubated in the presence of an excess of unlabeled VIP, which indicates that VIP has a physiological role in the lung.
Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27
TLDR
The entire amino acid sequence of the precursor, deduced from the nucleotide sequence, indicates that the precursor protein contains not only VIP but also a novel peptide of 27 amino acids.
Neuropeptides degranulate serous cells of ferret tracheal glands.
TLDR
The peptide-induced changes in gland cell morphology accompanying release of 35SO4-labeled macromolecules from tracheal explants of ferrets suggest that SP and VIP cause secretion from glands at least partially by stimulating exocytosis from serous cells.
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