Vasoactive intestinal peptide impairs leucocyte migration but fails to modify experimental murine colitis.

@article{Newman2005VasoactiveIP,
  title={Vasoactive intestinal peptide impairs leucocyte migration but fails to modify experimental murine colitis.},
  author={Rosie Newman and Natalia Cuan and Taline Hampartzoumian and Susan J. Connor and Andrew R. Lloyd and Michael C. Grimm},
  journal={Clinical and experimental immunology},
  year={2005},
  volume={139 3},
  pages={411-20}
}
Inflammatory bowel diseases are chronic inflammatory disorders of the gastrointestinal tract. Vasoactive intestinal peptide (VIP) is a neuropeptide with known anti-inflammatory activity. We have demonstrated previously that administration of VIP inhibits leucocyte migration in a murine model of delayed-type hypersensitivity, and anti-inflammatory efficacy is supported by other studies. The aim of this study was to investigate the VIP effects in a murine model of intestinal inflammation. Colitis… CONTINUE READING
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