Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit endotoxin-induced TNF-alpha production by macrophages: in vitro and in vivo studies.

@article{Delgado1999VasoactiveIP,
  title={Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit endotoxin-induced TNF-alpha production by macrophages: in vitro and in vivo studies.},
  author={Mario Delgado and David Del Pozo and C. Martinez and Javier Leceta and Juan Ram{\'o}n Calvo and Doina Ganea and Rosa P Gomariz},
  journal={Journal of immunology},
  year={1999},
  volume={162 4},
  pages={2358-67}
}
Vasoactive intestinal peptide (VIP) is a neuropeptide synthesized by immune cells that can modulate several immune aspects, including the function of cells involved in the inflammatory response, such as macrophages and monocytes. The production and release of cytokines by activated phagocytes are important events in the pathogenesis of ischemia-reperfusion injury. There is abundant evidence that the proinflammatory cytokine TNF-alpha is an important mediator of shock and organ failure… CONTINUE READING

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