Corpus ID: 26835056

Vasoactive intestinal peptide (VIP) as transmitter of inhibitory motor neurons of the gut: evidence from the use of selective VIP antagonists and VIP antiserum.

  title={Vasoactive intestinal peptide (VIP) as transmitter of inhibitory motor neurons of the gut: evidence from the use of selective VIP antagonists and VIP antiserum.},
  author={John R. Grider and Jean Rivier},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={253 2},
  • J. Grider, J. Rivier
  • Published 1 May 1990
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
The role of vasoactive intestinal peptide (VIP) in neurally mediated relaxation of guinea pig and rat intestine was examined with three putative VIP antagonists: a C-terminal sequence of VIP (VIP10-28), substituted analogs of VIP ([4-Cl-D-Phe6, Leu17]VIP) and growth hormone releasing factor (GRF) ([Ac-Tyr1, D-Phe2] GRF1-29). The three agents inhibited selectively relaxation induced by VIP and its homolog, peptide histidine isoleucine. Inhibition of VIP-induced relaxation in tenia coli and… Expand
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Vasoactive intestinal polypeptide induces neurogenic contraction of guinea-pig ileum. Involvement of acetylcholine and substance P
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Vasoactive intestinal peptide fragment VIP10-28 and active vasodilation in human skin.
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Lack of effect of vasoactive intestinal peptide antagonists on blood flow in the rat thyroid
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Interaction between atrial natriuretic peptide and vasoactive intestinal peptide in guinea pig cecal smooth muscle.
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Pituitary adenylate cyclase-activating polypeptide relaxes rat gastrointestinal smooth muscle.
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Expression of functional receptors for vasoactive intestinal peptide in freshly isolated and cultured gastric muscle cells
PHI and secretin were relatively more potent as relaxant agents than as inhibitors of 125I-VIP binding raising the possibility that PHI andsecretin could interact additionally with PHI- andSecretin-preferring receptors in mediating relaxation. Expand
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