Corpus ID: 26835056

Vasoactive intestinal peptide (VIP) as transmitter of inhibitory motor neurons of the gut: evidence from the use of selective VIP antagonists and VIP antiserum.

@article{Grider1990VasoactiveIP,
  title={Vasoactive intestinal peptide (VIP) as transmitter of inhibitory motor neurons of the gut: evidence from the use of selective VIP antagonists and VIP antiserum.},
  author={John R. Grider and Jean Rivier},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1990},
  volume={253 2},
  pages={
          738-42
        }
}
  • J. Grider, J. Rivier
  • Published 1 May 1990
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
The role of vasoactive intestinal peptide (VIP) in neurally mediated relaxation of guinea pig and rat intestine was examined with three putative VIP antagonists: a C-terminal sequence of VIP (VIP10-28), substituted analogs of VIP ([4-Cl-D-Phe6, Leu17]VIP) and growth hormone releasing factor (GRF) ([Ac-Tyr1, D-Phe2] GRF1-29). The three agents inhibited selectively relaxation induced by VIP and its homolog, peptide histidine isoleucine. Inhibition of VIP-induced relaxation in tenia coli and… Expand
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It is demonstrated that the synthetic peptides [4-Cl-D-Phe6,Leu17]VIP and the growth hormone releasing factor (GRF) analog [Ac-Tyr1,D- Phe2]GRF1-29-NH2 inhibit in a competitive manner the specific 125I-VIP binding to the same membrane preparation. Expand
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The results indicate that the three compounds tested are not effective inhibitors of VIP receptors in the thyroid vasculature and, therefore, they cannot be used in the investigation of the functional significance of endogenous VIP in the regulation of thyroid BF. Expand
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Vasoactive intestinal peptide release and l-citrulline production from isolated ganglia of the myenteric plexus: Evidence for regulation of vasoactive intestinal peptide release by nitric oxide
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The study provides the first direct evidence of nitric oxide production from enteric ganglia and implied that vasoactive intestinal peptide release is facilitated by and may be dependent on nitricoxide production. Expand
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