Vasoactive effects of eicosapentaenoic acid on isolated vascular smooth muscle

  title={Vasoactive effects of eicosapentaenoic acid on isolated vascular smooth muscle},
  author={Atsuo Yanagisawa and Allan M. Lefer},
  journal={Basic Research in Cardiology},
SummaryDietary intake of unsaturated fatty, acid of eicosapentaenoic acid (EPA) is thought to reduce the size and incidence of myocardial infarction. These beneficial effects are postulated to be due to chronic antithrombotic properties of EPA itself. We studied the possible direct effects of EPA on vascular smooth muscle as well as the ability of EPA to modify the vasoactivity of constrictor mediators in rabbit and cat aortic rings and isolated cat coronary arterics. EPA concentration… Expand
Pharmacological Characteristics of the Inhibitory Effects of Docosahexaenoic Acid on Vascular Contractions Studied in Rat Mesenteric Artery
DHA and EPA are found to more pronouncedly inhibit prostanoid receptor-mediated contractions than other constrictor responses of the mesenteric artery via endothelium-independent mechanisms. Expand
Eicosapentaenoic Acid Reduces Myocardial Injury Induced by Ischemia and Reperfusion in Rabbit Hearts
Eicosapentaenoic acid reduces myocardial infarct size, mainly via the opening of KCa channel-mediated and partially NO-mediated mechanisms in rabbit hearts, and significantly increased the n-3:n-6 ratio of PUFA. Expand
Selective and potent inhibitory effect of docosahexaenoic acid (DHA) on U46619-induced contraction in rat aorta
The present findings suggest that DHA and EPA elicit more selective inhibition against blood vessel contractions that are mediated through stimulation of prostanoid receptors than those through α-adrenoceptor stimulation or membrane depolarization. Expand
Vascular relaxation to omega-3 fatty acids: Comparison to sodium nitroprusside, nitroglycerin, papaverine, and D600
  • M. Engler
  • Medicine
  • Cardiovascular Drugs and Therapy
  • 2004
The results suggest that the mechanisms of vascular relaxation, such as cyclic nucleotide elevation and calcium antagonism of potential-operated channels, are different from those induced by the omega-3 fatty acids. Expand
All‑trans retinoic acid reduces endothelin‑1 expression and increases endothelial nitric oxide synthase phosphorylation in rabbits with atherosclerosis.
It was identified that plaque formation was alleviated in the ATRA group compared with the high fat group, as revealed by hematoxylin and eosin and oil red O staining, and a similar trend was reflected in the immunofluorescence results for endothelial permeability. Expand
Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: Their role and involvement in neurological disorders
Present knowledge of the functions of cyclooxygenases, lipoxygenase, and epoxygenased in brain and their association with neurodegenerative diseases are reviewed. Expand
The effect of omega-3 fatty acids on airway inflammation, hyperpnea-induced bronchoconstriction, and airway smooth muscle contractility in asthma
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Efeito do pré-tratamento com óleo de peixe sobre o infarto agudo do miocárdio em ratos.
De Souza Jr AL. Effect of the pretreatment with fish oil on myocardial infarction in rats. [Ph. D. thesis (Human Physiology)]. São Paulo: Instituto de Ciências Biomédicas, Universidade de São Paulo;Expand


Vascular reactivity and high dietary eicosapentaenoic acid.
The contractile effect of norepinephrine in isolated rat aortic strips is normally augmented by intrinsic prostaglandins, and this augmentation is diminished by dietary intake of EPA. Expand
Endothelium-dependent and nitrovasodilator-induced relaxation of vascular smooth muscle: role of cyclic GMP.
  • R. Rapoport, F. Murad
  • Chemistry, Medicine
  • Journal of cyclic nucleotide and protein phosphorylation research
  • 1983
The mechanisms by which endothelium-dependent relaxants and nitrovasodilators cause relaxation of vascular smooth muscle has been reviewed and it is suggested that an oxidized fatty acid or a derived free radical is responsible for activation of smooth muscle guanylate cyclase and increases in cyclic GMP levels. Expand
Vasoconstriction induced by noradrenaline and angiotensin II is antagonized by eicosapentaenoic acid independent of formation of trienoic eicosanoids
  • H. Juan, W. Sametz
  • Chemistry, Medicine
  • Naunyn-Schmiedeberg's Archives of Pharmacology
  • 2004
The results show that EPA is able to reduce the vasoconstriction induced by noradrenaline and A II in peripheral small vessels of the rabbit and appear to confirm the assumption that the increase in bleeding time caused by an EPA containing diet may depend on the reactivity of the injured blood vessel. Expand
Mechanism of coronary vasoconstriction induced by carbocyclic thromboxane A2.
The data suggest that the efficacy of calcium antagonists in coronary vasospasm may be related to their ability to noncompetitively inhibit thromboxane-induced vasoconstriction, and reduces external Ca2+ concentration to 0.63 mM significantly reduced coronary constriction over most of the CTA2 concentration-response range. Expand
Eicosapentaenoic Acid: Effect on Brain Prostaglandins, Cerebral Blood Flow and Edema in Ischemic Gerbils
This study indicates that eicosapentaenoic acid prevented post-ischemic cerebral edema and hypoperfu- sion, without affecting the levels of brain diene prostaglandin and thromboxane. Expand
Inhibition of Leukotriene Actions by the Calcium Channel Blocker, Nisoldipine 1
  • A. Lefer, A. Yanagisawa
  • Chemistry, Medicine
  • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1986
Nisoldipine, a calcium channel blocker having a highly potent effect on vascular smooth muscle relative to cardiac muscle, was tested to determine its anti-leukotriene properties and significantly attenuated the vasoconstrictor effects of both LTC4 and LTD4 in isolated perfuse cat coronary arteries and in isolated Langendorff perfused cat hearts. Expand
Actions of prostaglandins on isolated perfused cat coronary arteries.
Induction of hypoxia to a PO2 of 50 mmHg or increasing basal tome with 30 mM KCl did not diminish coronary artery response to prostaglandins, suggesting that prostag landins released from ischemic myocardial tissue may influence coronary arterial tone. Expand
Role of endothelial cells in relaxation of isolated arteries by bradykinin.
It is concluded that bradykinin relaxes canine and human arteries via a similar mechanism but that it relaxes cat and rabbit arteries by stimulating release of prostaglandins from as yet undefined cell types. Expand
The role of prostacyclin in vascular tissue.
Prostacyclin has interesting potential for clinical application in conditions where enhanced platelet aggregation is involved or to increase biocompatibility of extracorporeal circulation systems. Expand
Potent constriction of cat coronary arteries by hydroperoxides of arachidonic acid and its blockade by anti-inflammatory agents.
The omega-6 and omega-9 hydroperoxides of arachidonic acid caused dose-dependent constriction of cat coronary arteries and it is suggested that they have a direct effect on the arteries which can be antagonized by anti-inflammatory drugs. Expand