Vasculotropin/vascular endothelial growth factor induces differentiation in cultured osteoblasts.

  title={Vasculotropin/vascular endothelial growth factor induces differentiation in cultured osteoblasts.},
  author={V{\'e}ronique Midy and Jean Plou{\"e}t},
  journal={Biochemical and biophysical research communications},
  volume={199 1},
Vasculotropin/vascular endothelial growth factor (VAS/VEGF) is an angiogenic growth factor whose biological activity seems to be restricted in vitro to vascular endothelial cells. We describe here that fetal bovine osteoblasts (OB) bind VAS/VEGF but do not proliferate upon its addition. However VAS/VEGF induces migration, PTH-dependent cAMP accumulation and alkaline phosphatase increase when added to OB. The maximal effects reach levels comparable to that obtained with bone morphogenetic… CONTINUE READING

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