Vasculostatin inhibits intracranial glioma growth and negatively regulates in vivo angiogenesis through a CD36-dependent mechanism.

@article{Kaur2009VasculostatinII,
  title={Vasculostatin inhibits intracranial glioma growth and negatively regulates in vivo angiogenesis through a CD36-dependent mechanism.},
  author={B. Devinder Kaur and Sarah M. Cork and Eric M. Sandberg and Narra Sarojini Devi and Zhaobin Zhang and Philip A. Klenotic and Maria Febbraio and Hyunsuk Shim and Hui Mao and Carol Tucker-Burden and Roy L Silverstein and Daniel J. Brat and Jeffrey J. Olson and Erwin G Van Meir},
  journal={Cancer research},
  year={2009},
  volume={69 3},
  pages={1212-20}
}
Angiogenesis is a critical physiologic process that is appropriated during tumorigenesis. Little is known about how this process is specifically regulated in the brain. Brain angiogenesis inhibitor-1 (BAI1) is a brain-predominant seven-transmembrane protein that contains five antiangiogenic thrombospondin type-1 repeats (TSR). We recently showed that BAI1 is cleaved at a conserved proteolytic cleavage site releasing a soluble, 120 kDa antiangiogenic factor called vasculostatin (Vstat120… CONTINUE READING

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