Vasculoprotective effects of anti-tumor necrosis factor-alpha treatment in aging.

  title={Vasculoprotective effects of anti-tumor necrosis factor-alpha treatment in aging.},
  author={Anna Csisz{\'a}r and Nazar Labinskyy and Kira E. Smith and Aracelie Rivera and Zsuzsanna Orosz and Zoltan Ungvari},
  journal={The American journal of pathology},
  volume={170 1},
Vascular aging is associated with dysregulation of tumor necrosis factor (TNF)-alpha expression. TNF-alpha is a master regulator of vascular proatherogenic phenotypic changes, and it has been linked to endothelial dysfunction and apoptosis. To test the hypothesis that anti-TNF-alpha treatment exerts vasculoprotective effects in aging, aged (29 months old) F344 rats were treated with etanercept (1 mg/kg/week for 4 weeks), which binds and inactivates TNF-alpha. In aged carotid arteries… CONTINUE READING
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