Vasculitis in the Palmerston North mouse model of lupus: phenotype and cytokine production profile of infiltrating cells.

@article{Luzina1999VasculitisIT,
  title={Vasculitis in the Palmerston North mouse model of lupus: phenotype and cytokine production profile of infiltrating cells.},
  author={Irina G. Luzina and R H Knitzer and Sergei P. Atamas and William C. Gause and John C. Papadimitriou and Marcelo B. Sztein and Catherine E. Storrer and Barry S. Handwerger},
  journal={Arthritis and rheumatism},
  year={1999},
  volume={42 3},
  pages={561-8}
}
OBJECTIVE To define the phenotype of cells in the perivascular and vascular infiltrates of Palmerston North (PN) mice and the cytokines that those cells produce. METHODS Immunohistologic analysis, flow cytometric analysis, and reverse transcriptase-polymerase chain reaction (RT-PCR) studies were performed on tissues and cells from female PN mice and age-matched and sex-matched DBA/2 mice. RESULTS With aging, PN mice developed a female-predominant, lupus-like disease, with a severe systemic… CONTINUE READING

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