Vasculitic neuropathy in a patient with cryoglobulinemia and anti-MAG IGM monoclonal gammopathy.

@article{Thomas1992VasculiticNI,
  title={Vasculitic neuropathy in a patient with cryoglobulinemia and anti-MAG IGM monoclonal gammopathy.},
  author={Florian Patrick Thomas and R. E. Lovelace and Xin Sheng Ding and Saud Ahmed Sadiq and George W Petty and William H. Sherman and Norman Latov and Arthur P. Hays},
  journal={Muscle & nerve},
  year={1992},
  volume={15 8},
  pages={891-8}
}
A patient with sensorimotor mononeuritis multiplex had a type II cryoglobulin with an IgM kappa M-protein that appeared to contain monoclonal anti-MAG antibodies of the same isotype. A sural nerve biopsy demonstrated necrotizing arteritis and features of both axonal degeneration and demyelination. IgM kappa and C3 deposits were present on the myelin sheath of some residual nerve fibers. The findings suggest that the anti-MAG antibodies contributed to the myelin damage, while cryoprecipitates… CONTINUE READING

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