Vascularized and functional human liver from an iPSC-derived organ bud transplant

@article{Takebe2013VascularizedAF,
  title={Vascularized and functional human liver from an iPSC-derived organ bud transplant},
  author={T. Takebe and K. Sekine and M. Enomura and H. Koike and M. Kimura and T. Ogaeri and Ran-ran Zhang and Y. Ueno and Y. Zheng and N. Koike and S. Aoyama and Y. Adachi and H. Taniguchi},
  journal={Nature},
  year={2013},
  volume={499},
  pages={481-484}
}
A critical shortage of donor organs for treating end-stage organ failure highlights the urgent need for generating organs from human induced pluripotent stem cells (iPSCs). Despite many reports describing functional cell differentiation, no studies have succeeded in generating a three-dimensional vascularized organ such as liver. Here we show the generation of vascularized and functional human liver from human iPSCs by transplantation of liver buds created in vitro (iPSC-LBs). Specified hepatic… Expand
Regenerative medicine: Functional miniature human liver generated from stem cells
  • K. Ray
  • Medicine
  • Nature Reviews Gastroenterology &Hepatology
  • 2013
Functional 3D Human Liver Bud Assembled from MSC-Derived Multiple Liver Cell Lineages
Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 27 REFERENCES
Generation of functional human vascular network.
The reconstituted 'humanized liver' in TK-NOG mice is mature and functional.
...
1
2
3
...