Vascular thrombin receptor regulation in hypertensive rats.

  title={Vascular thrombin receptor regulation in hypertensive rats.},
  author={Q Capers and J\orn Bech Laursen and Toshiki Fukui and Sanjay Rajagopalan and Ichiro Mori and Pingping Lou and Bruce A. Freeman and W R Berrington and Kathy K. Griendling and David G Harrison and Marschall S. Runge and Robert W. Alexander and William R Taylor},
  journal={Circulation research},
  volume={80 6},
Thrombin has been implicated as an important mediator of vascular lesion formation in atherosclerosis and restenosis. To investigate a potential role for thrombin signaling in the vascular response to hypertension, we have studied thrombin receptor (TR) expression and regulation in hypertensive rats. Aortic TR mRNA was upregulated by angiotensin II (Ang II)-induced hypertension (10.7 +/- 2.5 times control, P < .02), which correlated with a 4-fold increase in thrombin-induced constriction in… CONTINUE READING


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