Vascular targets for cannabinoids: animal and human studies.

  title={Vascular targets for cannabinoids: animal and human studies.},
  author={Christopher P. Stanley and Saoirse Elizabeth O'Sullivan},
  journal={British journal of pharmacology},
  volume={171 6},
UNLABELLED Application of cannabinoids and endocannabinoids to perfused vascular beds or individual isolated arteries results in changes in vascular resistance. In most cases, the result is vasorelaxation, although vasoconstrictor responses are also observed. Cannabinoids also modulate the actions of vasoactive compounds including acetylcholine, methoxamine, angiotensin II and U46619 (thromboxane mimetic). Numerous mechanisms of action have been proposed including receptor activation, potassium… CONTINUE READING
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