Vascular stiffness in insulin resistance and obesity

  title={Vascular stiffness in insulin resistance and obesity},
  author={Guanghong Jia and Annayya R. Aroor and Vincent G DeMarco and Luis A. Martinez-Lemus and Gerald A. Meininger and James R. Sowers},
  booktitle={Front. Physiol.},
Obesity, insulin resistance, and type 2 diabetes are associated with a substantially increased prevalence of vascular fibrosis and stiffness, with attendant increased risk of cardiovascular and chronic kidney disease. Although the underlying mechanisms and mediators of vascular stiffness are not well understood, accumulating evidence supports the role of metabolic and immune dysregulation related to increased adiposity, activation of the renin angiotensin aldosterone system, reduced… CONTINUE READING
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