Vascular smooth muscle responses in pregnancy-induced hypertension.

@article{Ebeigbe1988VascularSM,
  title={Vascular smooth muscle responses in pregnancy-induced hypertension.},
  author={Anthony B. Ebeigbe and Mutairu Ezimokhai},
  journal={Trends in pharmacological sciences},
  year={1988},
  volume={9 12},
  pages={
          455-7
        }
}
PLASMA FROM NORMAL PREGNANT WOMEN ALTERS THE REACTIVITY OF RABBIT AORTIC SMOOTH MUSCLE WITH FUNCTIONAL ENDOTHELIUM
TLDR
The effects of normal human pregnant plasma on the reactivity of rabbit aortic rings with documented endothelium have been studied and their responses to noradrenaline, calcium chloride stimulation and potassium chloride‐induced relaxation were examined.
Contribution of vasomotion to vascular resistance: a comparison of arteries from virgin and pregnant rats.
TLDR
It is concluded that vasomotor activity may provide a mechanism to regulate vascular resistance and blood flow independent of static changes in arterial diameter and to contribute to the reduction in peripheral vascular resistance.
Sympathetic Nervous System Regulation in Human Normotensive and Hypertensive Pregnancies
TLDR
There is a lack of evidence-based knowledge on the physiology of blood pressure regulation during pregnancy, and there exist few effective strategies to mitigate the development of GH and preeclampsia in women who are known to be at increased risk.
In vitro vascular effects of cicletanine in pregnancy‐induced hypertension
TLDR
The results show that cicletanine inhibits contractile responses of human isolated inferior epigastric arteries by a mechanism unrelated to endothelial factors but associated with inhibition of calcium metabolism.
A role of ATP in modulating vasomotion during hypoxia in umbilical cord blood vessels
  • W. To
  • Biology, Medicine
  • 2012
TLDR
It is proposed that the findings of the present study is important in the understanding of the behaviour of human umbilical vessels in normal pregnancy, but may also have implications in the pathophysiology of complicated pregnancy such as pre-eclampsia.
Increased alpha-1 Adrenoceptor Expression in Pregnant Rats with Subrenal Aortic Coarctation
TLDR
It is suggested that subrenal aortic coarctation is a good animal model of pregnancy-induced hypertension and that α1-adrenoceptors participate in its physiopathology increasing their expression in a segment-dependent manner.
Mechanisms underlying the reduced endothelium‐dependent relaxation in human omental resistance artery in pre‐eclampsia
TLDR
It is suggested that the weaker responsiveness to NO seen in strips from pre‐eclamptic women may be partly due to a reduced smooth muscle responsiveness to cyclic GMP.
Depressed endothelium-dependent relaxation responses to acetylcholine and histamine in isolated human epigastric arteries from pre-eclamptic women
TLDR
The vasorelaxant effects of acetylcholine and histamine have been examined on 10−7m-noradrenaline-precontracted ring preparations of epigastric arteries from normotensive and pregnancy-induced hypertensive women, suggesting an impairment of endothelial function in pre-eclampsia.
Placental Cytokines and the Pathogenesis of Preeclampsia
The authors explore the hypothesis that tumor necrosis factor‐α (TNF‐α) and possibly other inflammatory cytokines are overproduced by the placenta in response to local ischemia/hypoxia contributing
Responses of isolated human epigastric arteries to histamine.
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References

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TLDR
Normal human pregnancy is characterized by vascular refractoriness to AII, and the action of progesterone or one of its metabolites appears to mediate the synthesis or the catabolism of locally produced prostag landins or prostaglandin-like agents.
Pregnancy-induced hypertension: development of a model in the pregnant sheep.
Responses of arterial smooth muscle from normotensive and pre-eclamptic subjects to the calcium channel agonist, Bay K 8644
  • A. Ebeigbe, M. Ezimokhai, C. P. Aloamaka
  • Biology, Medicine
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie
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TLDR
The results suggest that the increased peripheral vascular sensitivity associated with pregnancy-induced hypertension may be due, at least in part, to enhanced activity of the potential-sensitive Ca2+ channels in arterial smooth muscle plasmalemma.
Abnormal vascular function and morphology in pre-eclampsia: a study of isolated resistance vessels.
TLDR
The angiotensin II responsiveness of the vessels from the women with pre-eclampsia and from the non-pregnant women were similar, suggesting that pre- eClampsia is associated with an absence of the change in vascular function which normally occurs during pregnancy.
Clinical and pharmacological properties of calcium antagonists in essential hypertension in humans and spontaneously hypertensive rats.
TLDR
There might be an abnormally high sensitivity of the cell membrane system of vascular smooth muscle to both Ca2+ and Ca antagonists in patients with essential hypertension and in SHR, which proposes the membrane theory of essential hypertension--that membrane abnormalities lead to hypertension.
A novel potent vasoconstrictor peptide produced by vascular endothelial cells
TLDR
Cloning and sequencing of preproendothelin complementary DNA shows that mature endothelin is generated through an unusual proteolytic processing, and regional homologies to a group of neurotoxins suggest that endothelins is an endogenous modulator of voltage-dependent ion channels.
The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
TLDR
It is demonstrated that relaxation of isolated preparations of rabbit thoracic aorta and other blood vessels by ACh requires the presence of endothelial cells, and that ACh, acting on muscarinic receptors of these cells, stimulates release of a substance(s) that causes relaxation of the vascular smooth muscle.
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